Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Acute myocardial infarction (MI) causes sterile inflammation, which is characterized by
recruitment and activation of innate and adaptive immune system cells. Here we delineate …

Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in
several human cancers. MCL-1 is also highly expressed in myocardium, but its function in …

Rho GTPase is a master regulator controlling cytoskeleton in multiple contexts such as cell
migration, adhesion and cytokinesis. Of several Rho GTPases in mammals, the best …

Mitophagy, a mitochondria-specific form of autophagy, removes dysfunctional mitochondria
and is hence an essential process contributing to mitochondrial quality control. PTEN …

The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to
facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of …

Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central
issue to better understand cardiac physiology and diseases. Although significant progress …

Ras-homologous (Rho) A/Rho-kinase pathway plays an essential role in many cellular
functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its …

Cardiovascular disease (CVD) remains the leading cause of death globally, and heart
failure is a major component of CVD-related morbidity and mortality. The development of …