The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …
expression programmes. Significant advances have been made in understanding the …
The rise of regulatory RNA
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …
suggests that RNA is not only functional as a messenger between DNA and protein but also …
The emerging role of RNA modifications in the regulation of mRNA stability
SH Boo, YK Kim - Experimental & molecular medicine, 2020 - nature.com
Many studies have highlighted the importance of the tight regulation of mRNA stability in the
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
Detecting RNA modifications in the epitranscriptome: predict and validate
RNA modifications are emerging players in the field of post-transcriptional regulation of
gene expression, and are attracting a comparable degree of research interest to DNA and …
gene expression, and are attracting a comparable degree of research interest to DNA and …
Small and long non-coding RNAs: Past, present, and future
LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …
Biological roles of RNA m5C modification and its implications in Cancer immunotherapy
H Song, J Zhang, B Liu, J Xu, B Cai, H Yang… - Biomarker …, 2022 - Springer
Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first map** of N6-methyladenosine (m6A) and …
sciences in the post-genome era. Since the first map** of N6-methyladenosine (m6A) and …
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
JE Squires, HR Patel, M Nousch, T Sibbritt… - Nucleic acids …, 2012 - academic.oup.com
The modified base 5-methylcytosine (m 5 C) is well studied in DNA, but investigations of its
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data
With the explosive growth of biological sequences generated in the post-genomic era, one
of the most challenging problems in bioinformatics and computational biology is to …
of the most challenging problems in bioinformatics and computational biology is to …
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Y Wang, J Wei, L Feng, O Li, L Huang, S Zhou, Y Xu… - Molecular cancer, 2023 - Springer
Abstract Background RNA 5-methylcytosine (m5C) modification plays critical roles in the
pathogenesis of various tumors. However, the function and molecular mechanism of RNA …
pathogenesis of various tumors. However, the function and molecular mechanism of RNA …
The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
Q Huang, J Mo, Z Liao, X Chen, B Zhang - Cell Death & Disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is a widely investigated RNA modification in studies on
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …
the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal …