Oxindole has been shown to be a pharmacologically advantageous scaffold having many
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …

Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

A series of new pyrazolo-benzothiazole hybrids (7–26) were synthesised and screened for
their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung …

The fusion of pyrazole scaffold with other skeletons creates a class of attractive molecules,
demonstrating significant biological and chemical potentiality in the development of …

The α-and β-tubulins are the major polypeptide components of microtubules (MTs), which
are attractive targets for anticancer drug development. Indole derivatives display a variety of …

The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

An approach in modern medicinal chemistry to discover novel bioactive compounds is by
mimicking diverse complementary pharmacophores. In extension of this strategy, a new …

Bromide-catalyzed electrochemical trifluoromethylation/cyclization of N -arylacrylamides with low
catalyst loading - Organic Chemistry Frontiers (RSC Publishing) DOI:10.1039/C8QO00645H …