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Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment
In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options
The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …
multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its …
Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food
EFSA Panel on Contaminants in the Food Chain … - Efsa …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
Origin of hydroxylated brominated diphenyl ethers: natural compounds or man-made flame retardants?
Polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants. The
structurally related hydroxylated PBDEs (OH-PBDEs) and methoxylated PBDEs (MeO …
structurally related hydroxylated PBDEs (OH-PBDEs) and methoxylated PBDEs (MeO …
[HTML][HTML] Levels of omega 3 fatty acids, vitamin D, dioxins and dioxin-like PCBs in oily fish; a new perspective on the reporting of nutrient and contaminant data for risk …
Oily seafood is an important food source which contains several key nutrients beneficial for
human health. On the other hand, oily seafood also contains persistent organic pollutants …
human health. On the other hand, oily seafood also contains persistent organic pollutants …
In vitro and in vivo methods to assess pharmacokinetic drug– drug interactions in drug discovery and development
C Lu, L Di - Biopharmaceutics & drug disposition, 2020 - Wiley Online Library
Drug–drug interactions (DDIs) caused by the co‐administration of multiple drugs are major
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …
Intersection of AHR and Wnt signaling in development, health, and disease
AJ Schneider, AM Branam, RE Peterson - International journal of …, 2014 - mdpi.com
The AHR (aryl hydrocarbon receptor) and Wnt (wingless-related MMTV integration site)
signaling pathways have been conserved throughout evolution. Appropriately regulated …
signaling pathways have been conserved throughout evolution. Appropriately regulated …
Interleukin-8 induction by the environmental contaminant benzo (a) pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation
Benzo (a) pyrene (BP) is an environmental contaminant known to favor airway inflammation
likely through up-regulation of pro-inflammatory cytokines. The present study was designed …
likely through up-regulation of pro-inflammatory cytokines. The present study was designed …
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence …
Abstract In 2022 the World Health Organization (WHO) published updated 'Toxic
Equivalence Factors'(TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and …
Equivalence Factors'(TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and …
Mode of action and dose–response framework analysis for receptor-mediated toxicity: the aryl hydrocarbon receptor as a case study
Dioxins and dioxin-like compounds are tumor promoters that cause liver cancer in rats and
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …
mice. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this …