CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

Endothelial cells (ECs) constitute the innermost layer in all blood vessels to maintain the
structural integrity and microcirculation function for coronary microvasculature. Impaired …

Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to
explore non-conventional therapeutic measures to alleviate the burden of CVD on global …

Despite considerable efforts to prevent and treat ischemic cardiomyopathy (ICM), effective
therapies remain lacking, in part owing to the complexity of the underlying molecular …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …