Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Calmodulin is the best studied and prototypical example of the E–F-hand family of Ca 2+-
sensing proteins. Changes in intracellular Ca 2+ concentration regulate calmodulin in three …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-
resolution structures containing different metal ions bound to EF-hand sites have given new …

Calmodulin (CaM) is a ubiquitous, highly conserved, eukaryotic protein that binds to and
regulates a number of diverse target proteins involved in different functions such as …

The intracellular calcium sensor protein calmodulin (CaM) interacts with a large number of
proteins to regulate their biological functions in response to calcium stimulus. This molecular …

Abstract Small-conductance Ca2+-activated K+ channels (SK channels), are independent of
voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric …

Calcium pumps of the plasma membrane (also known as plasma membrane Ca 2+-
ATPases or PMCAs) are responsible for the expulsion of Ca 2+ from the cytosol of all …

A new version of the coarse-grained (CG) SIRAH force field for proteins has been
developed. Modifications to bonded and non-bonded interactions on the existing molecular …

Acute modulation of P/Q-type (α1A) calcium channels by neuronal activity-dependent
changes in intracellular Ca2+ concentration may contribute to short-term synaptic plasticity …