Ubiquitination-proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress
Y Li, S Li, H Wu - Cells, 2022 - mdpi.com
In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …
injury, repair the damage, and increase the tolerance to the stress. However, once the …
Ornithine aminotransferase, an important glutamate-metabolizing enzyme at the crossroads of multiple metabolic pathways
Ornithine δ-aminotransferase (OAT, EC 2.6. 1.13) catalyzes the transfer of the δ-amino
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …
group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and …
JKAMP inhibits the osteogenic capacity of adipose-derived stem cells in diabetic osteoporosis by modulating the Wnt signaling pathway through intragenic DNA …
S Peng, S Shi, G Tao, Y Li, D **ao, L Wang… - Stem Cell Research & …, 2021 - Springer
Background Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by
diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone …
diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone …
Sleep is bi-directionally modified by amyloid beta oligomers
Disrupted sleep is a major feature of Alzheimer's disease (AD), often arising years before
symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of …
symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of …
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport
Q Zhang, K **ao, JM Paredes, T Mamonova… - Journal of Biological …, 2019 - ASBMB
Na+-H+ exchanger regulatory factor-1 (NHERF1) is a PDZ protein that scaffolds membrane
proteins, including sodium–phosphate co-transport protein 2A (NPT2A) at the plasma …
proteins, including sodium–phosphate co-transport protein 2A (NPT2A) at the plasma …
A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain …
Abstract Background Obesity is heritable. It predisposes to many diseases. The objectives of
this study were to create a compendium of genes relevant to feeding behavior (FB) and/or …
this study were to create a compendium of genes relevant to feeding behavior (FB) and/or …
Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex
S Génier, J Degrandmaison, P Moreau… - Molecular biology of …, 2016 - Am Soc Cell Biol
Mechanisms that prevent aggregation and promote folding of nascent G protein–coupled
receptors (GPCRs) remain poorly understood. We identified chaperonin containing TCP-1 …
receptors (GPCRs) remain poorly understood. We identified chaperonin containing TCP-1 …
Rationalising the role of Keratin 9 as a biomarker for Alzheimer's disease
JL Richens, HL Spencer, M Butler, F Cantlay… - Scientific reports, 2016 - nature.com
Keratin 9 was recently identified as an important component of a biomarker panel which
demonstrated a high diagnostic accuracy (87%) for Alzheimer's disease (AD) …
demonstrated a high diagnostic accuracy (87%) for Alzheimer's disease (AD) …
Identification of the interactome of the DP1 receptor for Prostaglandin D2: Regulation of DP1 receptor signaling and trafficking by IQGAP1
L Fréchette, J Degrandmaison, C Binda… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Mechanisms governing localization, trafficking and signaling of G protein-
coupled receptors (GPCRs) are critical in cell function. Protein-protein interactions are …
coupled receptors (GPCRs) are critical in cell function. Protein-protein interactions are …
Quantitative proteomics reveals CLR interactome in primary human cells
D Manolis, S Hasan, A Maraveyas, DP O'Brien… - Journal of Biological …, 2024 - ASBMB
The G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) mediates
essential functions in several cell types and is implicated in cardiovascular pathologies, skin …
essential functions in several cell types and is implicated in cardiovascular pathologies, skin …