Highlights•Genomatica has developed a commercial bioprocess for the production of 1, 4-
butanediol from dextrose.•A systems biology approach enabled rapid identification and …

Significance: Cytochrome bd is a ubiquinol: oxygen oxidoreductase of many prokaryotic
respiratory chains with a unique structure and functional characteristics. Its primary role is to …

Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different
phenotypic outcomes—the inhibition of bacterial growth or, alternatively, cell death. Most …

By the time the complete genome sequence of the soil bacterium Pseudomonas putida
KT2440 was published in 2002 (Nelson et al.,) this bacterium was considered a potential …

Gene regulatory networks are powerful abstractions of biological systems. Since the advent
of high-throughput measurement technologies in biology in the late 1990s, reconstructing …

Hydrogen sulfide (H2S) impairs mitochondrial respiration by potently inhibiting the heme-
copper cytochrome c oxidase. Since many prokaryotes, including Escherichia (E.) coli …

This review focuses on the effects of hydrogen sulfide (H2S) on the unique bioenergetic
molecular machines in mitochondria and bacteria—the protein complexes of electron …

Bacteria often thrive in surface-attached communities, where they can form biofilms affording
them multiple advantages. In this sessile form, fluid flow is a key component of their …

The ATP synthase is a multicomponent enzyme that is largely conserved across the
kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by …

The reversible interconversion of molecular hydrogen and protons is one of the most ancient
microbial metabolic reactions and catalyzed by hydrogenases. A widespread yet largely …