Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the
central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) shows …

Human microglia are critically involved in Alzheimer's disease (AD) progression, as shown
by genetic and molecular studies. However, their role in tau pathology progression in human …

Oligodendrocyte precursor cells (OPCs) are a central nervous system resident population of
glia with a distinct molecular identity and an ever-increasing list of functions. OPCs generate …

Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a
robust, but poorly understood, neuroinflammatory response that contributes to the long-term …