The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

There is growing interest in the use of cnidarians (corals, sea anemones, jellyfish and
hydroids) to investigate the evolution of key aspects of animal development, such as the …

The topipotency of the germline is the full manifestation of the pluri-and multipotency of
embryonic and adult stem cells, thus the germline and stem cells must share common …

Cnidarians are astonishingly diverse in body form and lifestyle, including the presence of a
jellyfish stage in medusozoans and its absence in anthozoans. Here, we sequence the …

Turnover—constant component production and destruction—is ubiquitous in biology.
Turnover occurs across organisms and scales, including for RNAs, proteins, membranes …

We present an organism-wide, transcriptomic cell atlas of the hydrozoan medusa Clytia
hemisphaerica and describe how its component cell types respond to perturbation. Using …

The startling capacity of the amphibian Spemann organizer to induce naïve cells to form a
Siamese twin embryo with a second set of body axes is one of the hallmarks of …

First described by Randolph in 1897, the nature and main features of planarian neoblasts
have a long rambling history. While their morphologically undifferentiated features have long …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …