Surface-modified bacteria: synthesis, functionalization and biomedical applications

S Lin, F Wu, Y Zhang, H Chen, H Guo… - Chemical Society …, 2023‏ - pubs.rsc.org
The past decade has witnessed a great leap forward in bacteria-based living agents,
including imageable probes, diagnostic reagents, and therapeutics, by virtue of their unique …

Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems

C Xu, Q Ban, W Wang, J Hou, Z Jiang - Journal of Controlled Release, 2022‏ - Elsevier
Gut microbes are closely associated with most human health. When ingested orally,
probiotics can effectively regulate the composition and quantity of human intestinal …

Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field

X Ma, X Liang, Y Li, Q Feng, K Cheng, N Ma… - Nature …, 2023‏ - nature.com
Micro-nano biorobots based on bacteria have demonstrated great potential for tumor
diagnosis and treatment. The bacterial gene expression and drug release should be …

Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

MB Akolpoglu, Y Alapan, NO Dogan, SF Baltaci… - Science …, 2022‏ - science.org
Bacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale
materials, can deliver their payload to specific regions under magnetic control, enabling …

Upconversion dual-photosensitizer–expressing bacteria for near-infrared monochromatically excitable synergistic phototherapy

M Chen, Q Han, M Zhang, Y Liu, L Wang, F Yang… - Science …, 2024‏ - science.org
Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

T Harimoto, J Hahn, YY Chen, J Im, J Zhang… - Nature …, 2022‏ - nature.com
Living bacteria therapies have been proposed as an alternative approach to treating a broad
array of cancers. In this study, we developed a genetically encoded microbial encapsulation …

Foundations of gastrointestinal-based drug delivery and future developments

JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022‏ - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy

Z Li, Y Wang, J Liu, P Rawding, J Bu… - Advanced …, 2021‏ - Wiley Online Library
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …

Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches

S Lin, S Mukherjee, J Li, W Hou, C Pan, J Liu - Science advances, 2021‏ - science.org
Methods capable of maintaining gut microbiota homeostasis to prevent bacterial
translocation and infection under external threats are critical for multiple facets of human …

Biointerface mineralization generates ultraresistant gut microbes as oral biotherapeutics

Z Geng, X Wang, F Wu, Z Cao, J Liu - Science advances, 2023‏ - science.org
Despite the fact that oral microecologics are effective in modulating the gut microbiome, they
always suffer from multiple insults during the journey from manufacture to arrival at the …