Metabolomics has emerged as an invaluable tool that can be used along with genomics,
transcriptomics and proteomics to understand host–pathogen interactions at small-molecule …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Individuals affected
by the disease gradually lose their capacity for abstract thinking, understanding …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

Background The carbon metabolism of the blood stages of Plasmodium falciparum,
comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be …

The rapid emergence of metabolomics has enabled system-wide measurements of
metabolites in various organisms. However, advances in the mechanistic understanding of …

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria
parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both …

Mitochondrial ATP synthase plays a key role in inducing membrane curvature to establish
cristae. In Apicomplexa causing diseases such as malaria and toxoplasmosis, an unusual …

Nuclear glycogen was first documented in the early 1940s, but its role in cellular physiology
remained elusive. In this study, we utilized pure nuclei preparations and stable isotope …