[HTML][HTML] Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants

A Nasir, OK Afridi, S Ullah, H Khan, Q Bai - Pharmacological Research, 2024 - Elsevier
Sciatica characterized by irritation, inflammation, and compression of the lower back nerve,
is considered one of the most common back ailments globally. Currently, the therapeutic …

[HTML][HTML] On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review

S Fakhri, F Abbaszadeh, M Jorjani - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …

Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy. Role of NGF/AKT/GSK-3β pathway

SA El-Marasy, MM AbouSamra… - Chemico-Biological …, 2023 - Elsevier
Diabetic peripheral neuropathy (DPN) is a common diabetic complication. Chrysin (CHY)
has many biological properties but poor oral bioavailability. This study investigates the effect …

An Insight on the Biomedical Potential of Portuguese Propolis from Gerês

C Araújo, RD Oliveira, F Pinto-Ribeiro… - Foods, 2022 - mdpi.com
Osteoarthritis (OA), a progressive degenerative disease of weight-bearing joints, is the
second leading cause of disability in the world. Despite all the advances and research over …

A comprehensive review on therapeutic potential of chrysin in brain related disorders

A Goyal, G Singh, A Verma - CNS & Neurological Disorders …, 2023 - ingentaconnect.com
Brain disorders are currently one of the world's most serious and difficult health issues.
These brain disorders are accountable for a massive number of morbidities and mortalities …

Geniposide Alleviates Neuropathic Pain in CCI Rats by Inhibiting the EGFR/PI3K/AKT Pathway And Ca2+ Channels

D Zhang, Q Chen, L Yao - Neurotoxicity Research, 2022 - Springer
Neuropathic pain (NP) is a common disorder among individuals worldwide, but there is still
no effective treatment for NP. The EGFR pathway promotes NP nociceptive sensitization and …

Self-Nanoemulsion Intrigues the Gold Phytopharmaceutical Chrysin: In Vitro Assessment and Intrinsic Analgesic Effect

SM Elhoseny, NM Saleh, MM Meshali - AAPS PharmSciTech, 2024 - Springer
Chrysin is a natural flavonoid with a wide range of bioactivities. Only a few investigations
have assessed the analgesic activity of chrysin. The lipophilicity of chrysin reduces its …

Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

XH Do, TN Nguyen, TC Dang… - Asian Pacific Journal …, 2023 - journals.lww.com
Objective: To investigate the anti-inflammatory and analgesic effects of Solanum
procumbens on complete Freund's adjuvant-induced arthritis rat models. Methods: We …

[PDF][PDF] An Insight on the Biomedical Potential of Portuguese Propolis from Gerês. Foods 2022, 11, 3431

C Araújo, RD Oliveira, F Pinto-Ribeiro… - 2022 - academia.edu
Osteoarthritis (OA), a progressive degenerative disease of weight-bearing joints, is the
second leading cause of disability in the world. Despite all the advances and research over …

Pain relieving impacts of chrysin via down-regulation of hypothalamic Tac1 and CGRP in a Rat model of formalin-induced pain

F Mahmoudi, K Haghighat, H Khazali - Jorjani Biomedicine Journal - goums.ac.ir
Background: Chrysin is a natural bioactive compound belonging to the flavonoid group. The
pain-relieving effects of chrysin have been reported in several studies; however, the …