The handling of highly pathogenic viruses, whether for diagnostic or research purposes,
often requires an inactivation step. This article reviews available inactivation techniques …

To study integral membrane proteins, one has to extract them from the membrane—the step
that is typically achieved by the application of detergents. In this mini-review, we summarize …

Abstract α-Synuclein (α-Syn) aggregation is closely associated with Parkinson's disease
neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and …

Membrane proteins are still heavily under-represented in the protein data bank (PDB),
owing to multiple bottlenecks. The typical low abundance of membrane proteins in their …

Supramolecular solvents (SUPRAS) have progressively become a suitable alternative to
organic solvents for sample preparation in chromatographic analysis. The inherent …

Detergents are used in molecular biology laboratories every day. They are present in cell
lysis buffers (eg, in kits for plasmid isolation), in electrophoresis and blotting buffers, and …

Generating stable conditions for membrane proteins after extraction from their lipid bilayer
environment is essential for subsequent characterization. Detergents are the most widely …

Extraction of membrane proteins from biological membranes is usually accomplished with
the help of detergents. This unit describes the use of detergents to solubilize and purify …

Microbially derived surfactants, called biosurfactants, provide a promising alternative to
synthetic surfactants, displaying better availability and being generally nontoxic and …

Membrane proteins are largely underrepresented among available atomic-resolution
structures. The use of detergents in protein purification procedures hinders the formation of …