[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

First‐trimester uterine artery Doppler and adverse pregnancy outcome: a meta‐analysis involving 55 974 women

L Velauthar, MN Plana, M Kalidindi… - … in Obstetrics & …, 2014 - Wiley Online Library
Objectives To determine the accuracy with which uterine artery Doppler in the first trimester
of pregnancy predicts pre‐eclampsia and fetal growth restriction, particularly early‐onset …

Placental origins of preeclampsia: challenging the current hypothesis

B Huppertz - Hypertension, 2008 - Am Heart Assoc
Preeclampsia is a major contributor to the maternal and neonatal mortality and morbidity. 1,
2 It is the 2nd largest cause of maternal mortality worldwide and affects 5% to 7% of …

Prediction and prevention of recurrent preeclampsia

JR Barton, BM Sibai - Obstetrics & Gynecology, 2008 - journals.lww.com
Women with a history of previous preeclampsia are at increased risk of preeclampsia and
other adverse pregnancy outcomes in subsequent pregnancies. The magnitude of this risk is …

A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the …

JP Kusanovic, R Romero… - The Journal of …, 2009 - Taylor & Francis
Objective. Changes in the maternal plasma concentrations of angiogenic (placental growth
factor (PlGF) and vascular endothelial growth factor (VEGF)) and anti-angiogenic factors …

The critical role of abnormal trophoblast development in the etiology of preeclampsia

B Huppertz - Current pharmaceutical biotechnology, 2018 - ingentaconnect.com
Background: The pregnancy pathology preeclampsia is still among the leading causes of
maternal and perinatal morbidity and mortality. At the same time, its etiology is far from being …

Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review

S Kuc, EJ Wortelboer, BB van Rijn… - Obstetrical & …, 2011 - journals.lww.com
Abstract Preeclampsia (PE) affects 1% to 2% of pregnant women and is a leading cause of
maternal and perinatal morbidity and mortality worldwide. The clinical syndrome of PE …

Trophoblast invasion and oxygenation of the placenta: measurements versus presumptions

B Huppertz, G Weiss, G Moser - Journal of reproductive immunology, 2014 - Elsevier
Invasion of extravillous trophoblast into maternal tissues has a profound effect on the
oxygenation of the placenta and hence the fetus. The main route of trophoblast invasion is …

Screening for pre-eclampsia–lessons from aneuploidy screening

HS Cuckle - Placenta, 2011 - Elsevier
BACKGROUND: Antenatal screening for aneuploidy is an established routine clinical
practice worldwide. The same statistical methodology, developed and refined over three …