The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell
populations and their progeny, oligodendrocytes, emerge from three distinct regions in a …

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

Astrocytes are complex glial cells with numerous fine cellular processes that infiltrate the
neuropil and interact with synapses. The mechanisms that control the establishment of …

Cerebral organoids provide an accessible system for investigations of cellular composition,
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …

Brain circuits undergo substantial structural changes during development, driven by the
formation, stabilization, and elimination of synapses. Synaptic connections continue to …

The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …