Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
Application of next generation sequencing for diagnosis and clinical management of drug-resistant tuberculosis: updates on recent developments in the field
N Dookie, A Khan, N Padayatchi, K Naidoo - Frontiers in Microbiology, 2022 - frontiersin.org
The World Health Organization's End TB Strategy prioritizes universal access to an early
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
diagnosis and comprehensive drug susceptibility testing (DST) for all individuals with …
Environmental and genetic modulation of the phenotypic expression of antibiotic resistance
Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …
and generally an acquired mechanism results in a predictable increase in phenotypic …
The molecular clock of Mycobacterium tuberculosis
The molecular clock and its phylogenetic applications to genomic data have changed how
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
we study and understand one of the major human pathogens, Mycobacterium tuberculosis …
Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …
Beyond the SNP threshold: identifying outbreak clusters using inferred transmissions
Whole-genome sequencing (WGS) is increasingly used to aid the understanding of
pathogen transmission. A first step in analyzing WGS data is usually to define “transmission …
pathogen transmission. A first step in analyzing WGS data is usually to define “transmission …
The relationship between transmission time and clustering methods in Mycobacterium tuberculosis epidemiology
Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
High-resolution map** of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain
Y Xu, I Cancino-Muñoz, M Torres-Puente… - PLoS …, 2019 - journals.plos.org
Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …
Comprehensive whole-genome sequencing and reporting of drug resistance profiles on clinical cases of Mycobacterium tuberculosis in New York State
Whole-genome sequencing (WGS) is a newer alternative for tuberculosis (TB) diagnostics
and is capable of providing rapid drug resistance profiles while performing species …
and is capable of providing rapid drug resistance profiles while performing species …