Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …

Rates of spontaneous mutation critically determine the genetic diversity and evolution of
RNA viruses. Although these rates have been characterized in vitro and in cell culture …

Hepatitis C virus (HCV) remains a significant global health challenge. Approximately 50
million people were living with chronic hepatitis C based on the World Health Organization …

The treatment of HCV infection has evolved at an extremely rapid pace over the past few
years. The development of direct-acting antiviral agents, which potently inhibit different …

Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An
estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection …

Background & Aims Direct-acting antiviral (DAA) regimens provide a cure in> 95% of
patients with chronic HCV infection. However, in some patients in whom therapy fails …

Despite remarkable progress in the treatment of hepatitis C virus (HCV) infection, it remains
a significant global health burden, necessitating the development of an effective prophylactic …

Abstract Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical …