The acid sphingomyelinase/ceramide system in COVID-19
Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …
[HTML][HTML] Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial
Importance Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of
an excessive immune response. Fluvoxamine may prevent clinical deterioration by …
an excessive immune response. Fluvoxamine may prevent clinical deterioration by …
Effect of AXS-05 (dextromethorphan-bupropion) in major depressive disorder: a randomized double-blind controlled trial
H Tabuteau, A Jones, A Anderson… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Altered glutamatergic neurotransmission is implicated in the pathogenesis of
major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA …
major depressive disorder. AXS-05 (dextromethorphan-bupropion) is an oral NMDA …
Crystal structure of the human σ1 receptor
The human σ1 receptor is an enigmatic endoplasmic-reticulum-resident transmembrane
protein implicated in a variety of disorders including depression, drug addiction, and …
protein implicated in a variety of disorders including depression, drug addiction, and …
Nanotechnological approaches in prostate cancer therapy: integration of engineering and biology
Nanocarriers have received special attention in biomedicine for the treatment of various
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers …
[HTML][HTML] Efficacy and safety of AXS-05 (dextromethorphan-bupropion) in patients with major depressive disorder: a phase 3 randomized clinical trial (GEMINI)
DV Iosifescu, A Jones, C O'Gorman… - The Journal of …, 2022 - psychiatrist.com
Objective: Altered glutamatergic neurotransmission has been implicated in the pathogenesis
of depression. This trial evaluated the efficacy and safety of AXS-05 (dextromethorphan …
of depression. This trial evaluated the efficacy and safety of AXS-05 (dextromethorphan …
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis
DA Rosen, SM Seki, A Fernández-Castañeda… - Science translational …, 2019 - science.org
Sepsis is an often deadly complication of infection in which systemic inflammation damages
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …
the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the …
New advances in general biomedical applications of PAMAM dendrimers
Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …
considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by …
Polypharmacology–foe or friend?
JU Peters - Journal of medicinal chemistry, 2013 - ACS Publications
Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …
[HTML][HTML] Disease-drug and drug-drug interaction in COVID-19: Risk and assessment
COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …