Multi omics applications in biological systems

CD Gutierrez Reyes, G Alejo-Jacuinde… - Current Issues in …, 2024 - mdpi.com
Traditional methodologies often fall short in addressing the complexity of biological systems.
In this regard, system biology omics have brought invaluable tools for conducting …

A review of the role of epigenetic studies for intramuscular fat deposition in beef cattle

BK Abebe, J Wang, J Guo, H Wang, A Li, L Zan - Gene, 2024 - Elsevier
Intramuscular fat (IMF) deposition profoundly influences meat quality and economic value in
beef cattle production. Meanwhile, contemporary developments in epigenetics have opened …

Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage …

Y Lin, Y Tang, O Yi, J Zhu, Z Su, G Li, H Zhou… - Journal of …, 2024 - Springer
The characteristic features of the rheumatoid arthritis (RA) microenvironment are synovial
inflammation and hyperplasia. Therefore, there is a growing interest in develo** a suitable …

Structural and molecular properties of mumps virus inclusion bodies

H Katoh, R Kimura, T Sekizuka, K Matsuoka… - Science …, 2024 - science.org
Viral RNA synthesis of mononegaviruses occurs in cytoplasmic membraneless organelles
called inclusion bodies (IBs). Here, we report that IBs of mumps virus (MuV), which is the …

Machine learning in onco-pharmacogenomics: A path to precision medicine with many challenges

A Mondello, M Dal Bo, G Toffoli… - Frontiers in Pharmacology, 2024 - frontiersin.org
Over the past two decades, Next-Generation Sequencing (NGS) has revolutionized the
approach to cancer research. Applications of NGS include the identification of tumor specific …

Biomarkers in high grade serous ovarian cancer

M Bates, BM Mohamed, F Lewis, S O'Toole… - … et Biophysica Acta (BBA …, 2024 - Elsevier
High-grade serous ovarian cancer (HGSC) is the most common subtype of ovarian cancer.
HGSC patients typically present with advanced disease, which is often resistant to …

Rediscovering the human thymus through cutting-edge technologies

F Pala, LD Notarangelo, M Bosticardo - Journal of Experimental …, 2024 - rupress.org
Recent technological advances have transformed our understanding of the human thymus.
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …

The Next, Next-Generation of Sequencing, Promising to Boost Research and Clinical Practice

KR Kumar, MJ Cowley, RL Davis - Seminars in Thrombosis …, 2024 - thieme-connect.com
Five years on from our award-winning review on Nextgeneration sequencing and emerging
technologies, 1 a rapid pace of fundamental advances has markedly altered the landscape …

Multiplexed spatial transcriptomics methods and the application of expansion microscopy

A Fortner, O Bucur - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
While spatial transcriptomics has undeniably revolutionized our ability to study cellular
organization, it has driven the development of a great number of innovative transcriptomics …

[HTML][HTML] Advancements in pathology: Digital transformation, precision medicine, and beyond

S Ahuja, S Zaheer - Journal of Pathology Informatics, 2024 - Elsevier
Pathology, a cornerstone of medical diagnostics and research, is undergoing a revolutionary
transformation fueled by digital technology, molecular biology advancements, and big data …