Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …

Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …

SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …

Peripheral neuropathy is a common neurodegenerative condition characterized by
numbness, tingling, pain, and weakness that frequently starts in the distal limbs. Arising from …

The past 20 years of research on axon degeneration has revealed fine details on how NAD
biology controls axonal survival. Extensive data demonstrate that the NAD precursor NMN …

Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …

Sterile alpha and TIR motif containing 1 (SARM1) is an inducible NADase that localizes to
mitochondria throughout neurons and senses metabolic changes that occur after injury …

Programmed axon death is a druggable pathway of axon degeneration that has garnered
considerable interest from pharmaceutical companies as a promising therapeutic target for …