Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad
physiological processes including the regulation of vascular tone, neurotransmission …

Hypertension remains a global health crisis. High blood pressure is the number one
modifiable risk factor in the onset and progression of cardiovascular disease. Despite many …

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for
enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As …

Chronic calorie restriction (CR) improves cardiovascular function and several other
physiological markers of healthspan. However, CR is impractical in non-obese older …

Aging is associated with a decline in physiological function and exercise performance.
These effects are mediated, at least in part, by an age-related decrease in the bioavailability …

With increased numbers of older people a higher burden of neurological disorders
worldwide is predicted. Stroke and other cerebrovascular diseases do not necessarily …

Many oral bacteria reduce inorganic nitrate, a natural part of a vegetable-rich diet, into nitrite
that acts as a precursor to nitric oxide, a regulator of vascular tone and neurotransmission …

As our world's population ages, cardiovascular diseases (CVD) will become an increasingly
urgent public health problem. A key antecedent to clinical CVD and many other chronic …

• Acute or chronic (NO3−) intake also improves muscle contractile function in a variety of
subject populations, including healthy young and middle-aged individuals, athletes, patients …

Consumption of beetroot juice (BRJ) supplements has become popular among athletes
because beets tend to be rich in nitrate (NO 3−), which can enhance exercise performance …