The skin is an organ harboring several types of immune cells that participate in innate and
adaptive immune responses. The immune system of the skin comprises both skin cells and …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Granulomas are complex cellular structures composed predominantly of macrophages and
lymphocytes that function to contain and kill invading pathogens. Here, we investigated the …

Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

Cell-type composition of intact bulk tissues can vary across samples. Deciphering cell-type
composition and its changes during disease progression is an important step toward …

Leprosy reactions are acute inflammatory episodes that complicate the course of a
Mycobacterium leprae infection and are the major cause of leprosy-associated pathology …

Leprosy is still a considerable health threat in pockets of several low and middle income
countries worldwide where intense transmission is witnessed, and often results in …

Background Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is often
late-or misdiagnosed leading to irreversible disabilities. Blood transcriptomic biomarkers …

Background Influenza infects tens of millions of people every year in the USA. Other than
notable risk groups, such as children and the elderly, it is difficult to predict what …

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human
pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted …