Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Cutaneous malignant melanomas originate primarily within epidermal melanocytic cells.
Melanoma cells share many characteristics with melanocyte precursors, suggesting that …

Background: Cell–cell communication in a tumor microenvironment is vital to tumorigenesis,
tumor progression and therapy. Intercellular communication inference helps understand …

The most critical stage in initiation of melanoma metastasis is the radial to vertical growth
transition, yet the triggers of this transition remain elusive. We suggest that the …

Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals
with more invasive placentation (for example, humans) are more vulnerable to malignancy …

Besides intrinsic changes, malignant cells also release soluble signals that reshape their
microenvironment. Among these signals is WNT1-inducible signaling pathway protein 1 …

ALDH1A1 is a cytosolic enzyme upregulated in tumor cells, involved in detoxifying cells from
reactive aldehydes and in acquiring resistance to chemotherapeutic drugs. Its expression …

Melanoma is the deadliest form of skin cancer. Current challenges facing the management
of melanoma include accurate prediction of individuals who will respond to adjuvant …

Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in
melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis …

Despite strong indications that interactions between melanoma and lymphatic vessels
actively promote melanoma progression, the molecular mechanisms are not yet completely …