Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Ca 2+ is a universal carrier of biological information: it controls cell life from its origin at
fertilization to its end in the process of programmed cell death. Ca 2+ is a conventional …

Evolution has exploited the chemical properties of Ca 2+, which facilitate its reversible
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …

Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …

There is growing evidence that cardiac dysfunction in patients with chronic epilepsy could
play a pathogenic role in sudden unexpected death in epilepsy (SUDEP). Recent animal …

Background MicroRNA (miRNA) expression in atrial tissue has been implicated in
pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels …

CaMKII has been shown to be activated during different cardiac pathological processes, and
CaMKII-dependent mechanisms contribute to pathological cardiac remodeling, cardiac …

Both type 1 and type 2 diabetes are associated with increased risk of cardiovascular
disease. This is in part attributed to the effects of hyperglycemia on vascular endothelial and …