CD8+ T cells in the cancer-immunity cycle
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
K Chamoto, T Yaguchi, M Tajima, T Honjo - Nature Reviews …, 2023 - nature.com
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
[HTML][HTML] Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
C Yang, J **, Y Yang, H Sun, L Wu, M Shen, X Hong… - Immunity, 2022 - cell.com
The incidence and mortality rates of many non-reproductive human cancers are generally
higher in males than in females. However, the immunological mechanism underlying sexual …
higher in males than in females. However, the immunological mechanism underlying sexual …
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss …
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
[HTML][HTML] Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate,
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …
[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …
Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool
K Bresser, L Kok, AC Swain, LA King, L Jacobs… - Nature …, 2022 - nature.com
Clonal expansion is a core aspect of T cell immunity. However, little is known with respect to
the relationship between replicative history and the formation of distinct CD8+ memory T cell …
the relationship between replicative history and the formation of distinct CD8+ memory T cell …
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain.
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …