Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

Lipid droplet formation is a defining histological feature in clear-cell renal cell carcinoma
(ccRCC) but the underlying mechanisms and importance of this biological behaviour have …

The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …

Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the
peritoneal cavity. Visceral adipocytes promote this process by providing fatty acids (FAs) for …