Fluorescent fusion proteins have revolutionized examination of proteins in living cells. Still,
studies using these proteins are met with criticism because proteins are modified and …

Microtubules have long been considered an ideal target for anticancer drugs because of the
essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is …

The past several years have seen major advances in our understanding of the mechanisms
of microtubule destabilization by oncoprotein18/stathmin (Op18/stathmin) and related …

Microtubules are hollow tubes essential for many cellular functions such as cell polarization
and migration, intracellular trafficking and cell division. They are polarized polymers …

In the leading edge of migrating cells, a subset of microtubules exhibits net growth in a Rac1-
and p21-activated kinase-dependent manner. Here, we explore the possibility of whether …

Microtubules are fibrous elements in the cytoplasm of eukaryotic cells, where they perform a
wide variety of functions. Microtubules are major organizers of the cell interior and are vitally …

Stathmin is a p53-regulated protein known to influence microtubule dynamics. Because
several chemotherapeutic agents used to treat breast cancer alter the dynamic equilibrium …

Microtubule-associated proteins (MAPs) function to regulate the assembly dynamics and
organization of microtubule polymers. Upstream regulation of MAP activities is the major …

Epithelial cell sheets line the organ and body surfaces and the specialized barrier functions
of these epithelia regulate the exchange of substances with the outside environment and …

The XMAP215/Dis1 MAP family is thought to regulate microtubule plus-end assembly in part
by antagonizing the catastrophe-promoting function of kin I kinesins, yet XMAP215/Dis1 …