For about three decades, the chemistry of cation radicals derived from organic molecules
had received a major impetus from mass spectrometry. This was because cation radicals …

Electron capture dissociation (ECD) MS is proving to be unusually valuable for “top down”
protein sequencing and identification/localization of posttranslational modifications, because …

Overall charge unchanged: Disulfide bonds in gaseous polypeptide cations can be cleaved
efficiently by ultraviolet photodissociation (UVPD) at 157 nm (see scheme). Unlike electron …

This Letter reviews efforts made to elucidate the mechanism by which electron-capture and
electron-transfer dissociation bond cleavages occur in mass spectrometry. The primary …

Insulin is a hormone vital for glucose homeostasis, and insulin-degrading enzyme (IDE)
plays a key role in its clearance. IDE exhibits a remarkable specificity to degrade insulin …

Mechanical force applied along a disulfide bond alters its rate of reduction. We here aimed
at quantifying the direct effect of force onto the chemical reactivity of a sulfur-sulfur bond in …

Electron capture dissociation (ECD) of the peptide Substance P (SubP) complexed with
divalent metals has been investigated. ECD of [SubP+ H+ M] 3+(M 2+= Mg 2+-Ba 2+ and Mn …

We have made use of classical dynamics trajectory simultions and ab initio electronic
structure calculations to estimate the cross sections with which electrons are attached (in …

Characterisation and identification of disulfide bridges is an important aspect of structural
elucidation of proteins. Covalent cysteine-cysteine contacts within the protein give rise to …

The disulfide bond is an important post-translational modification to form and maintain the
native structure and biological functions of proteins. Characterization of disulfide bond …