The centriole is an evolutionarily conserved macromolecular structure that is crucial for the
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …

The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Centrioles are ancient organelles that build centrosomes, the major microtubule-organizing
centers of animal cells. Extra centrosomes are a common feature of cancer cells. To …

Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Formation of one procentriole next to each pre-existing centriole is essential for centrosome
duplication, robust bipolar spindle assembly and maintenance of genome integrity …

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting
genome instability. The mechanisms governing centrosome assembly and function are …

Cilia are conserved, microtubule-based cell surface projections that emanate from basal
bodies, membrane-docked centrioles. The beating of motile cilia and flagella enables cells …

Centrosomes play an important role in various cellular processes, including spindle
formation and chromosome segregation. They are composed of two orthogonally arranged …

Microtubule plus-end tracking proteins (+ TIPs) are structurally and functionally diverse
factors that accumulate at the growing microtubule plus-ends, connect them to various …