Drug targets for corona virus: A systematic review
Abstract The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21 th
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this …
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this …
[HTML][HTML] Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19
N Yang, HM Shen - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA
viruses and some of them are known to cause severe respiratory diseases in human …
viruses and some of them are known to cause severe respiratory diseases in human …
Should COVID-19 concern nephrologists? Why and to what extent? The emerging impasse of angiotensin blockade
Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney
diseases, including acute kidney injury, and examine the potential effects of ARBs on the …
diseases, including acute kidney injury, and examine the potential effects of ARBs on the …
Drug development and medicinal chemistry efforts toward SARS‐coronavirus and Covid‐19 therapeutics
The COVID‐19 pandemic caused by SARS‐CoV‐2 infection is spreading at an alarming
rate and has created an unprecedented health emergency around the globe. There is no …
rate and has created an unprecedented health emergency around the globe. There is no …
[HTML][HTML] Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
Cardiac arrhythmias in COVID-19 infection
SM Kochav, E Coromilas, A Nalbandian… - Circulation …, 2020 - Am Heart Assoc
A 76-year-old man with a history of diabetes mellitus type II and hypertension presented with
progressive dyspnea, weakness, and myalgias for 6 days. On admission, vital signs were …
progressive dyspnea, weakness, and myalgias for 6 days. On admission, vital signs were …
Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications
COVID-19 extra-pulmonary features include several endocrine manifestations and these are
becoming strongly clinically relevant in patients affected influencing disease severity and …
becoming strongly clinically relevant in patients affected influencing disease severity and …
COVID-19 Research: Pandemic Versus “Paperdemic”, Integrity, Values and Risks of the “Speed Science”
RJ Dinis-Oliveira - Forensic sciences research, 2020 - academic.oup.com
Scientific integrity is a learned skill. When researchers and students learn integrity in
laboratories or in the classroom, they are empowered to use similar principles in other …
laboratories or in the classroom, they are empowered to use similar principles in other …
The spike protein of SARS-CoV—a target for vaccine and therapeutic development
L Du, Y He, Y Zhou, S Liu, BJ Zheng… - Nature Reviews …, 2009 - nature.com
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused
by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is …
by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is …
Repurposing sigma-1 receptor ligands for COVID-19 therapy?
JM Vela - Frontiers in Pharmacology, 2020 - frontiersin.org
Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health
professionals with the unique challenge of treating patients. With no time to discover new …
professionals with the unique challenge of treating patients. With no time to discover new …