Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …

Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …

Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Recurrent medulloblastoma and ependymoma are universally lethal, with no approved
targeted therapies and few candidates presently under clinical evaluation. Nearly all …

Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …

Cancer-related deaths are mainly caused by metastatic spread of tumor cells from the
primary lesion to distant sites via the blood circulation. Understanding the mechanisms of …

Cancer metastasis is the process by which primary cancer cells invade through the
lymphatic or blood vessels to distant sites. The molecular mechanisms by which cancer cells …