Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Importance The etiologic factors of late-life depression are still poorly understood. Recent
evidence suggests that microvascular dysfunction is associated with depression, which may …

Previous meta-analyses of structural MRI studies have shown diffuse cortical and sub-
cortical abnormalities in unipolar depression. However, the presence of duplicate …

Background Vascular depression is regarded as a subtype of late-life depression
characterized by a distinct clinical presentation and an association with cerebrovascular …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Objective The main purpose of this review was to synthesise evidence on ECT's effects on
brain's structure. Method A systematic literature review of longitudinal studies of depressed …

Reports of the association between cardiovascular risk factors and depression in later life
are inconsistent; to establish the nature of their association seems important for prevention …

BACKGROUND: Until more recently, most studies have examined the changes in brain gray
matter in major depressive disorder (MDD) with less studies focusing on understanding …

We sought to determine if an association exists between overall, deep, and periventricular
white matter hyperintensities and depression. We searched PubMed (Medline) and Scopus …

Recent neuroimaging studies have characterized the pathophysiology of late-life depression
(LLD) as a dysfunction of the brain networks involved in the regulation of emotion …