The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

Cancer nanomedicines have provided promising treatment strategies for the regression of
several types of cancer, although there still exists a need for significant advances to improve …

Anti-cancer drugs with various mechanisms emerge in succession, but most of free
therapeutics are accompanied by some disadvantages, such as poor safety and …

Background Although anti-programmed cell death protein 1 (PD-1) immunotherapy is
greatly effective in melanoma treatment, low response rate and treatment resistance …

Nanotechnology has brought about a significant revolution in drug delivery, and research in
this domain is increasingly focusing on understanding the role of nanoparticle (NP) …

Background Lymphatic metastasis has been associated with poor prognosis in bladder
cancer patients with limited therapeutic options. Emerging evidence shows that heat shock …

Degradable polymers (both biomacromolecules and several synthetic polymers) for
biomedical applications have been promising very much in the recent past due to their low …

Gene-based therapies have emerged as a new modality for combating a myriad of currently
incurable diseases. However, the fragile nature of gene therapeutics has significantly …

Herein, we developed a photolabile spherical nucleic acid (PSNA) for carrier-free and near-
infrared (NIR) photocontrolled self-delivery of small-interfering RNA (siRNA) and antisense …

Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene
therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment …