Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. It is
characterized by deposition of extracellular matrix proteins, like collagen and fibronectin in …

Mitochondrial biogenesis and mitochondrial DNA (mtDNA) maintenance depend on
coordinated expression of genes in the nucleus and mitochondria. A variety of intracellular …

Mutations in parkin lead to early-onset autosomal recessive Parkinson's disease (PD) and
inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the …

Mitochondrial respiratory function is impaired in the target tissues of patients with
mitochondrial diseases and declines with age in various human tissues. It is generally …

Mitochondria do not only produce less ATP, but they also increase the production of reactive
oxygen species (ROS) as byproducts of aerobic metabolism in the aging tissues of the …

Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …

Most research to date has focused on epigenetic modifications in the nuclear genome, with
little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been …

Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality
that is characterized by abnormal scarring of the lung parenchyma. There has been a recent …

The in vivo cellular impact of age‐associated mitochondrial DNA mutations is unknown. We
hypothesized that mitochondrial DNA deletion mutations contribute to the fiber atrophy and …

Background: Studies emphasize the importance of particulate matter (PM) in the formation of
reactive oxygen species and inflammation. We hypothesized that these processes can …