Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-
function relationship in these regions is poorly understood, in part because the primary …

Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid
chromatography in combination with tandem mass spectrometry is a standard approach in …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Aurora is the name given to a family of highly conserved protein kinases with essential roles
in many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The microtubule-binding interface of the kinetochore is of central importance in chromosome
segregation. Although kinetochore components that stabilize, translocate on, and affect the …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …