[HTML][HTML] Data-analysis strategies for image-based cell profiling

JC Caicedo, S Cooper, F Heigwer, S Warchal, P Qiu… - Nature …, 2017 - nature.com
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic
differences among a variety of cell populations. It paves the way to studying biological …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Neuropilin-1 is a host factor for SARS-CoV-2 infection

JL Daly, B Simonetti, K Klein, KE Chen, MK Williamson… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for host cell …

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution

R Gao, SM Asano, S Upadhyayula, I Pisarev, DE Milkie… - Science, 2019 - science.org
INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer

KH Gouin III, N Ing, JT Plummer, CJ Rosser… - Nature …, 2021 - nature.com
Neoadjuvant chemotherapy (NAC) prior to surgery and immune checkpoint therapy (ICT)
have revolutionized bladder cancer management. However, stratification of patients that …

Image biomarker standardisation initiative

A Zwanenburg, S Leger, M Vallières, S Löck - arxiv preprint arxiv …, 2016 - arxiv.org
The image biomarker standardisation initiative (IBSI) is an independent international
collaboration which works towards standardising the extraction of image biomarkers from …

Test-time augmentation for deep learning-based cell segmentation on microscopy images

N Moshkov, B Mathe, A Kertesz-Farkas, R Hollandi… - Scientific reports, 2020 - nature.com
Recent advancements in deep learning have revolutionized the way microscopy images of
cells are processed. Deep learning network architectures have a large number of …

Accelerated RNA detection using tandem CRISPR nucleases

TY Liu, GJ Knott, DCJ Smock, JJ Desmarais… - Nature chemical …, 2021 - nature.com
Direct, amplification-free detection of RNA has the potential to transform molecular
diagnostics by enabling simple on-site analysis of human or environmental samples …

A BaSiC tool for background and shading correction of optical microscopy images

T Peng, K Thorn, T Schroeder, L Wang, FJ Theis… - Nature …, 2017 - nature.com
Quantitative analysis of bioimaging data is often skewed by both shading in space and
background variation in time. We introduce BaSiC, an image correction method based on …

Practical considerations for quantitative light sheet fluorescence microscopy

CM Hobson, M Guo, HD Vishwasrao, Y Wu, H Shroff… - Nature …, 2022 - nature.com
Fluorescence microscopy has evolved from a purely observational tool to a platform for
quantitative, hypothesis-driven research. As such, the demand for faster and less phototoxic …