Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

KE Bohnsack, C Höbartner, MT Bohnsack - Genes, 2019 - mdpi.com
5-methylcytosine (m5C) is an abundant RNA modification that's presence is reported in a
wide variety of RNA species, including cytoplasmic and mitochondrial ribosomal RNAs …

The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark

L Trixl, A Lusser - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
It is a well‐known fact that RNA is the target of a plethora of modifications which currently
amount to over a hundred. The vast majority of these modifications was observed in the two …

RNA modification: mechanisms and therapeutic targets

L Qiu, Q **g, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

RNA modifications in cardiovascular diseases, the potential therapeutic targets

Y Wu, S Zhan, Y Xu, X Gao - Life Sciences, 2021 - Elsevier
More than one hundred RNA modifications decorate the chemical and topological properties
of these ribose nucleotides, thereby executing their biological functions through post …

Post-transcriptional regulation by cytosine-5 methylation of RNA

R García-Vílchez, A Sevilla, S Blanco - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
The recent advent of high-throughput sequencing technologies coupled with RNA
modifications detection methods has allowed the detection of RNA modifications at single …

[HTML][HTML] TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy

A Lewinska, J Adamczyk-Grochala, M Wnuk - Biochimica et Biophysica …, 2023 - Elsevier
Affected landscape of RNA modifications is frequently observed in different cancer cells that
can be associated with the development of cancer cell phenotypic traits such as sustained …

Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration

S Xue, H Xu, Z Sun, H Shen, S Chen, J Ouyang… - Biochemical and …, 2019 - Elsevier
Human TRDMT1 is a transfer RNA (tRNA) methyltransferase for cytosine-5 methylation and
has been suggested to be involved in the regulation of numerous developmental processes …

[HTML][HTML] Potential regulatory role of epigenetic RNA methylation in cardiovascular diseases

S Komal, LR Zhang, SN Han - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide,
especially in develo** countries. To date, several approaches have been proposed for the …

[HTML][HTML] Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation …

A Lewinska, J Adamczyk-Grochala, E Kwasniewicz… - Redox Biology, 2018 - Elsevier
Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous
processes, however its biological significance and underlying molecular mechanisms …

TRDMT1 exhibited protective effects against LPS‐induced inflammation in rats through TLR4‐NF‐κB/MAPK‐TNF‐α pathway

Z Li, X Qi, X Zhang, L Yu, L Gao, W Kong… - Animal Models and …, 2022 - Wiley Online Library
Background Inflammation is a complex physiological and pathological process. Although
many types of inflammation are well characterized, their physiological functions are largely …