Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in
the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin …

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug
Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers …

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Pt (IV) complexes act as prodrugs that are activated inside cancer cells releasing cytotoxic Pt
(II) drugs such as cisplatin as well as two axial ligands. These ligands can be used to confer …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

Multiple drug resistance is the main reason for chemotherapeutic failure in lung cancer
patients with complex molecular mechanisms. LncRNA-MALAT1 plays functional roles in the …

Platinum drugs are extensively used in the clinic to treat cancer, often leading to a palliative
response rather than a cure. While DNA is considered to be the primary target of platinum …