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Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
Using exonucleases for aptamer characterization, engineering, and sensing
Conspectus Aptamers are short, single-stranded nucleic acids that have been selected from
random libraries to bind specific molecules with high affinity via an in vitro method termed …
random libraries to bind specific molecules with high affinity via an in vitro method termed …
High-Affinity Aptamers for In Vitro and In Vivo Cocaine Sensing
The ability to quantify cocaine in biological fluids is crucial for both the diagnosis of
intoxication and overdose in the clinic as well as investigation of the drug's pharmacological …
intoxication and overdose in the clinic as well as investigation of the drug's pharmacological …
Nuclease-assisted selection of slow-off rate aptamers
O Alkhamis, J Canoura, L Wang, Y ** Aptamer-Based Colorimetric Opioid Tests
Opioids collectively cause over 80,000 deaths in the United States annually. The ability to
rapidly identify these compounds in seized drug samples on-site will be essential for …
rapidly identify these compounds in seized drug samples on-site will be essential for …
DNA Aptamer–Cyanine Complexes as Generic Colorimetric Small‐Molecule Sensors
Aptamers are promising biorecognition elements for sensors. However, aptamer‐based
assays often lack the requisite levels of sensitivity and/or selectivity because they typically …
assays often lack the requisite levels of sensitivity and/or selectivity because they typically …