Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

Over the past decade, there has been much interest in the regulation of telomerase, the
enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in …

Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

The cell phenotypes of senescence and crisis operate to circumscribe the proliferative
potential of mammalian cells, suggesting that both are capable of operating in vivo to …

Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer
degeneration of multiple tissues,,. Patient-specific induced pluripotent stem (iPS) cells …

Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that
restrains cancer progression at premalignant stages, in part by causing telomere …

Whole genome analyses have facilitated the discovery of clinically relevant genetic
alterations in a variety of diseases, most notably cancer. A prominent example of this was …

Telomere length and cell function can be preserved by the human reverse transcriptase
telomerase (hTERT), which synthesizes the new telomeric DNA from a RNA template, but is …