Despite tremendous efforts in basic research and a growing number of clinical trials aiming
to find effective treatments, amyotrophic lateral sclerosis (ALS) remains an incurable …

Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …

Objective Informative biomarkers are an urgent need in the management of amyotrophic
lateral sclerosis. Serum cardiac troponin T is elevated in the majority of amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder characterized by
relentless and progressive loss of motor neurons. A molecular diagnosis, supported by the …

Objectives Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disorder. Diagnosis
is challenging due to its clinical heterogeneity and the absence of definitive diagnostic tools …

Amyotrophic lateral sclerosis (ALS) currently lacks the useful diagnostic biomarkers. The
current diagnosis of ALS is mainly depended on the clinical manifestations, which …

Simple Summary Amyotrophic lateral sclerosis (ALS) is the most common form of Motor
Neuron Disease and is traditionally associated with motor cortex, brainstem and spinal cord …

The motor neuron disease amyotrophic lateral sclerosis (ALS) is a devastating condition
with limited treatment options. The past few years have witnessed a ram** up of …

The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …

Platform trials present potential advantages over stand-alone clinical trials. Here, we
describe the operational framework of the HEALEY Amyotrophic Lateral Sclerosis Platform …