Pluripotent stem cells show a remarkable ability to self-organize and differentiate in vitro in
three-dimensional aggregates, known as organoids or organ spheroids, and to recapitulate …

Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Human brain wrinkling has been implicated in neurodevelopmental disorders and yet its
origins remain unknown. Polymer gel models suggest that wrinkling emerges spontaneously …

The human cerebral cortex possesses distinct structural and functional features that are not
found in the lower species traditionally used to model brain development and disease …

The mammalian brain is composed of an outer layer of gray matter, consisting of cell bodies,
dendrites, and unmyelinated axons, and an inner core of white matter, consisting primarily of …

An expansion of the cerebral neocortex is thought to be the foundation for the unique
intellectual abilities of humans. It has been suggested that an increase in the proliferative …

Non-coding regions comprise most of the human genome and harbor a significant fraction of
risk alleles for neuropsychiatric diseases, yet their functions remain poorly defined. We …

The biophysical features of neurons shape information processing in the brain. Cortical
neurons are larger in humans than in other species, but it is unclear how their size affects …

Metabolism has recently emerged as a major target of genes implicated in the evolutionary
expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B …

The rapid growth of the human cortex during development is accompanied by the folding of
the brain into a highly convoluted structure,,. Recent studies have focused on the genetic …