Sustainable click reactions: use of greener reaction media in the synthesis of 1, 2, 3-triazoles

LA Martinho, CKZ Andrade - Tetrahedron, 2024 - Elsevier
Heterocyclic compounds are widely found in nature, more specifically, five-or six-membered
rings nitrogen heterocycles are important in the synthesis of biologically active compounds …

[HTML][HTML] Click-chemistry mediated synthesis of OTBN-1, 2, 3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities

DP Vala, AD Miller, A Atmasidha, MP Parmar… - Bioorganic …, 2024 - Elsevier
There is a continuous and pressing need to establish new brain-penetrant bioactive
compounds with anti-cancer properties. To this end, a new series of 4′-((4-substituted-4, 5 …

Alkoxy-functionalised dihydropyrimido [4, 5-b] quinolinones enabling anti-proliferative and anti-invasive agents

SG Patel, I Sharma, MP Parmar, J Nogales… - Chemical …, 2024 - pubs.rsc.org
In this communication, we explored the synthesis of novel alkoxy-functionalised
dihydropyrimido [4, 5-b] quinolinones using a microwave-assisted multicomponent reaction …

[HTML][HTML] Indoles in Drug Design and Medicinal Chemistry

BA Babalola, M Malik, O Olowokere, A Adebesin… - European Journal of …, 2025 - Elsevier
Indole derivatives represent a significant class of compounds in medicinal chemistry due to
their diverse biological activities and structural versatility. These compounds are central to …

Synthesis, characterization of new electrochemical activated sulfadiazine azo dyes and its theoretical studies with LFPs, antioxidant application

MN TH, I Pushpavathi, RS Vishwanath, KS BE… - Materials Science and …, 2024 - Elsevier
The present study describes the optoelectronic, LFPs visualizations and DPPH scavenging
activity using sulfadiazine azo dyes. The resulting azo product was obtained through a diazo …

One-pot synthesis of tetrahydropyrimidinecarboxamides enabling in vitro anticancer activity: a combinative study with clinically relevant brain-penetrant drugs

DB Upadhyay, J Nogales, JA Mokariya, RM Vala… - RSC …, 2024 - pubs.rsc.org
In this study, we describe a one-pot three-component synthesis of bioactive
tetrahydopyrimidinecarboxamide derivatives employing lanthanum triflate as a catalyst. Out …

Thiazolidine-2, 4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation

G Singh, R Singh, V Monga, S Mehan - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Twelve 3, 5-disubstituted-thiazolidine-2, 4-dione (TZD) hybrids were synthesized using
solution phase chemistry. Continuing our previous work, nine O-modified ethyl vanillin (8a–i) …

Two Step One‐Pot Synthesis of 7‐Azaindole Linked 1,2,3‐Triazole Hybrids: In‐Vitro and In‐Silico Antimicrobial Evaluation

K Sharma, B Lal, R Kumar Tittal, K Lal, L Vats… - …, 2024 - Wiley Online Library
Herein, we report design, synthesis and characterization of a new library of 7‐azaindole N‐
ethyl linked 1, 2, 3‐triazoles containing ethylene as a spacer unit, and evaluation of all the …

Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1, 2, 3-triazole-4-yl) propoxy) benzaldehydes: In vitro antimicrobial, antimalarial activities and In silico …

MA Al-Salehi, MP Parmar, DP Rajani, HM Patel… - Journal of Molecular …, 2024 - Elsevier
In this work, we have developed new derivatives of 4-(3-(1-substituted/unsubstituted phenyl-
1H-1, 2, 3-triazol-4-yl) propoxy) benzaldehydes 3 (ao) in good to excellent yield through the …

Design and synthesis of new 1, 2, 3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment

AA Al-Karmalawy, MA Zeidan, AA Elmaaty… - Bioorganic …, 2025 - Elsevier
In this current work, we dedicated efforts to designing and synthesizing new 1, 2, 3-triazole-
analogues (5a-d),(6a-d), and (7a-c) to act as dual VEGFR-2 and telomerase inhibitors with …