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Sustainable click reactions: use of greener reaction media in the synthesis of 1, 2, 3-triazoles
LA Martinho, CKZ Andrade - Tetrahedron, 2024 - Elsevier
Heterocyclic compounds are widely found in nature, more specifically, five-or six-membered
rings nitrogen heterocycles are important in the synthesis of biologically active compounds …
rings nitrogen heterocycles are important in the synthesis of biologically active compounds …
[HTML][HTML] Click-chemistry mediated synthesis of OTBN-1, 2, 3-Triazole derivatives exhibiting STK33 inhibition with diverse anti-cancer activities
There is a continuous and pressing need to establish new brain-penetrant bioactive
compounds with anti-cancer properties. To this end, a new series of 4′-((4-substituted-4, 5 …
compounds with anti-cancer properties. To this end, a new series of 4′-((4-substituted-4, 5 …
Alkoxy-functionalised dihydropyrimido [4, 5-b] quinolinones enabling anti-proliferative and anti-invasive agents
In this communication, we explored the synthesis of novel alkoxy-functionalised
dihydropyrimido [4, 5-b] quinolinones using a microwave-assisted multicomponent reaction …
dihydropyrimido [4, 5-b] quinolinones using a microwave-assisted multicomponent reaction …
[HTML][HTML] Indoles in Drug Design and Medicinal Chemistry
Indole derivatives represent a significant class of compounds in medicinal chemistry due to
their diverse biological activities and structural versatility. These compounds are central to …
their diverse biological activities and structural versatility. These compounds are central to …
Synthesis, characterization of new electrochemical activated sulfadiazine azo dyes and its theoretical studies with LFPs, antioxidant application
The present study describes the optoelectronic, LFPs visualizations and DPPH scavenging
activity using sulfadiazine azo dyes. The resulting azo product was obtained through a diazo …
activity using sulfadiazine azo dyes. The resulting azo product was obtained through a diazo …
One-pot synthesis of tetrahydropyrimidinecarboxamides enabling in vitro anticancer activity: a combinative study with clinically relevant brain-penetrant drugs
In this study, we describe a one-pot three-component synthesis of bioactive
tetrahydopyrimidinecarboxamide derivatives employing lanthanum triflate as a catalyst. Out …
tetrahydopyrimidinecarboxamide derivatives employing lanthanum triflate as a catalyst. Out …
Thiazolidine-2, 4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation
Twelve 3, 5-disubstituted-thiazolidine-2, 4-dione (TZD) hybrids were synthesized using
solution phase chemistry. Continuing our previous work, nine O-modified ethyl vanillin (8a–i) …
solution phase chemistry. Continuing our previous work, nine O-modified ethyl vanillin (8a–i) …
Two Step One‐Pot Synthesis of 7‐Azaindole Linked 1,2,3‐Triazole Hybrids: In‐Vitro and In‐Silico Antimicrobial Evaluation
Herein, we report design, synthesis and characterization of a new library of 7‐azaindole N‐
ethyl linked 1, 2, 3‐triazoles containing ethylene as a spacer unit, and evaluation of all the …
ethyl linked 1, 2, 3‐triazoles containing ethylene as a spacer unit, and evaluation of all the …
Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1, 2, 3-triazole-4-yl) propoxy) benzaldehydes: In vitro antimicrobial, antimalarial activities and In silico …
In this work, we have developed new derivatives of 4-(3-(1-substituted/unsubstituted phenyl-
1H-1, 2, 3-triazol-4-yl) propoxy) benzaldehydes 3 (ao) in good to excellent yield through the …
1H-1, 2, 3-triazol-4-yl) propoxy) benzaldehydes 3 (ao) in good to excellent yield through the …
Design and synthesis of new 1, 2, 3-triazole derivatives as VEGFR-2/telomerase downregulatory candidates endowed with apoptotic potential for cancer treatment
In this current work, we dedicated efforts to designing and synthesizing new 1, 2, 3-triazole-
analogues (5a-d),(6a-d), and (7a-c) to act as dual VEGFR-2 and telomerase inhibitors with …
analogues (5a-d),(6a-d), and (7a-c) to act as dual VEGFR-2 and telomerase inhibitors with …