Current gaps in sepsis immunology: new opportunities for translational research
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …
[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts
Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …
CD4 T cell responses and the sepsis-induced immunoparalysis state
Sepsis remains a major cause of death in the United States and worldwide, and costs
associated with treating septic patients place a large burden on the healthcare industry …
associated with treating septic patients place a large burden on the healthcare industry …
Immune dysregulation in sepsis: experiences, lessons and perspectives
M Cao, G Wang, J **e - Cell Death Discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …
Sepsis-induced T cell immunoparalysis: the ins and outs of impaired T cell immunity
IJ Jensen, FV Sjaastad, TS Griffith… - The Journal of …, 2018 - journals.aai.org
Sepsis results in a deluge of pro-and anti-inflammatory cytokines, leading to lymphopenia
and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in …
and chronic immunoparalysis. Sepsis-induced long-lasting immunoparalysis is defined, in …
Advances in immune monitoring approaches for sepsis-induced immunosuppression
RQ Yao, C Ren, LY Zheng, ZF **a, YM Yao - Frontiers in immunology, 2022 - frontiersin.org
Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of
note is that majority of patients have experienced a severe immune depression during and …
note is that majority of patients have experienced a severe immune depression during and …
Microbial exposure enhances immunity to pathogens recognized by TLR2 but increases susceptibility to cytokine storm through TLR4 sensitization
MA Huggins, FV Sjaastad, M Pierson, TA Kucaba… - Cell reports, 2019 - cell.com
Microbial exposures can define an individual's basal immune state. Cohousing specific
pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes …
pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes …
Allergen exposure functionally alters influenza-specific CD4+ Th1 memory cells in the lung
MJ Rüterbusch, BD Hondowicz, KK Takehara… - Journal of Experimental …, 2023 - rupress.org
CD4+ lung-resident memory T cells (TRM) generated in response to influenza infection
confer effective protection against subsequent viral exposures. Whether these cells can be …
confer effective protection against subsequent viral exposures. Whether these cells can be …
Lymphopenia in sepsis: a narrative review
Z Wang, W Zhang, L Chen, X Lu, Y Tu - Critical Care, 2024 - Springer
This narrative review provides an overview of the evolving significance of lymphopenia in
sepsis, emphasizing its critical function in this complex and heterogeneous disease. We …
sepsis, emphasizing its critical function in this complex and heterogeneous disease. We …