Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

A major resistance mechanism in Gram-negative bacteria is the production of β-lactamase
enzymes. Originally recognized for their ability to hydrolyze penicillins, emergent β …

The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in
clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and …

ABSTRACT Introduction: Antimicrobial resistance in Gram-negative pathogens is a
significant threat to global health. β-Lactams (BL) are one of the safest and most-prescribed …

Carbapenems are vital antibiotics, but their efficacy is increasingly compromised by metallo-
β-lactamases (MBLs). Here we report the discovery and optimization of potent broad …

Due to the fact that there is a steadily increasing trend in the area of antimicrobial resistance
in microorganisms, there is a need to look for new treatment alternatives. One of them is the …

α-Aminoboronic acids and their derivatives are useful as bioactive agents. Thus far, three
compounds containing an α-aminoboronate motif have been approved by the Food and …

β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low
toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms …

Class D β-lactamases are composed of 14 families and the majority of the member enzymes
are included in the OXA family. The genes for class D β-lactamases are frequently identified …