Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and
metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate …

Virtually all pathogenic stimuli activate Müller cells. Reactive Müller cells exert protective
and toxic effects on photoreceptors and neurons. They contribute to oxidative stress and …

The field of hemichannels is closely related to the purinergic signaling and both areas have
been growing in parallel. Hemichannels open in response to a wide range of stressful …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Sustained increase in intraocular pressure represents a major risk factor for eye disease, yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …

Glaucoma is one of the leading causes of irreversible blindness in the world and remains a
major public health problem. To date, incomplete knowledge of this disease's …

This nontechnical review is focused upon educating the reader on optic nerve head
biomechanics in both aging and disease along two main themes: what is known about how …

Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in
Alzheimer's disease (AD) in which all proposed treatments investigated in murine models …