Late-stage functionalization for improving drug-like molecular properties

NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

Metallaphotoredox catalysis for sp 3 C–H functionalizations through hydrogen atom transfer (HAT)

J Zhang, M Rue** - Chemical Society Reviews, 2023 - pubs.rsc.org
In recent years, the integration of photocatalytic hydrogen atom transfer (HAT) with transition
metal catalysis has emerged as a formidable strategy for the construction of C (sp3)–carbon …

Late-stage C–H functionalization offers new opportunities in drug discovery

L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Radical C(sp3)–H functionalization and cross-coupling reactions

DL Golden, SE Suh, SS Stahl - Nature Reviews Chemistry, 2022 - nature.com
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Strategies and Mechanisms of First-Row Transition Metal-Regulated Radical C–H Functionalization

X Wang, J He, YN Wang, Z Zhao, K Jiang… - Chemical …, 2024 - ACS Publications
Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Catalyzing electrosynthesis: a homogeneous electrocatalytic approach to reaction discovery

JC Siu, N Fu, S Lin - Accounts of chemical research, 2020 - ACS Publications
Conspectus Electrochemistry has been used as a tool to drive chemical reactions for over
two centuries. With the help of an electrode and a power source, chemists are bestowed with …

3d transition metals for C–H activation

P Gandeepan, T Müller, D Zell, G Cera… - Chemical …, 2018 - ACS Publications
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

The persistent radical effect in organic synthesis

D Leifert, A Studer - Angewandte Chemie International Edition, 2020 - Wiley Online Library
Radical–radical couplings are mostly nearly diffusion‐controlled processes. Therefore, the
selective cross‐coupling of two different radicals is challenging and not a synthetically …

Electronic control over site-selectivity in hydrogen atom transfer (HAT) based C (sp 3)–H functionalization promoted by electrophilic reagents

M Galeotti, M Salamone, M Bietti - Chemical Society Reviews, 2022 - pubs.rsc.org
The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

The interplay of polar effects in controlling the selectivity of radical reactions

A Ruffoni, RC Mykura, M Bietti, D Leonori - Nature Synthesis, 2022 - nature.com
Radical reactivity is a powerful tool for molecular construction that often provides bond-
forming strategies and retrosynthetic disconnections complementary to those available …