Finding function in novel targets: C. elegans as a model organism
T Kaletta, MO Hengartner - Nature reviews Drug discovery, 2006 - nature.com
Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed
into an important model for biomedical research, particularly in the functional …
into an important model for biomedical research, particularly in the functional …
The utility of single nucleotide polymorphisms in inferences of population history
Single nucleotide polymorphisms (SNPs) represent the most widespread type of sequence
variation in genomes, yet they have only emerged recently as valuable genetic markers for …
variation in genomes, yet they have only emerged recently as valuable genetic markers for …
Rapid SNP discovery and genetic map** using sequenced RAD markers
Single nucleotide polymorphism (SNP) discovery and genoty** are essential to genetic
map**. There remains a need for a simple, inexpensive platform that allows high-density …
map**. There remains a need for a simple, inexpensive platform that allows high-density …
A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity
A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing
by Pseudomonas aeruginosa led to the identification of two genes required for pathogen …
by Pseudomonas aeruginosa led to the identification of two genes required for pathogen …
An initial map of insertion and deletion (INDEL) variation in the human genome
Although many studies have been conducted to identify single nucleotide polymorphisms
(SNPs) in humans, few studies have been conducted to identify alternative forms of natural …
(SNPs) in humans, few studies have been conducted to identify alternative forms of natural …
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
K Jia, D Chen, DL Riddle - 2004 - journals.biologists.com
The highly conserved target-of-rapamycin (TOR) protein kinases control cell growth in
response to nutrients and growth factors. In mammals, TOR has been shown to interact with …
response to nutrients and growth factors. In mammals, TOR has been shown to interact with …
The million mutation project: a new approach to genetics in Caenorhabditis elegans
O Thompson, M Edgley, P Strasbourger… - Genome …, 2013 - genome.cshlp.org
We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each
sequenced to a target depth of 15-fold coverage, to provide the research community with …
sequenced to a target depth of 15-fold coverage, to provide the research community with …
A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous
system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically …
system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically …
Manganese: recent advances in understanding its transport and neurotoxicity
The present review is based on presentations from the meeting of the Society of Toxicology
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
Common Sequence Polymorphisms Sha** Genetic Diversity in Arabidopsis thaliana
The genomes of individuals from the same species vary in sequence as a result of different
evolutionary processes. To examine the patterns of, and the forces sha**, sequence …
evolutionary processes. To examine the patterns of, and the forces sha**, sequence …