Glaucoma is a multifactorial optic degenerative neuropathy characterized by the loss of
retinal ganglion cells. It is a combination of vascular, genetic, anatomical, and immune …

The glaucomas are a group of conditions leading to irreversible sight loss and characterised
by progressive loss of retinal ganglion cells. Although not always elevated, intraocular …

Background Primary open angle glaucoma (POAG) is a chronic, progressive ocular disease
causing loss of the optic nerve rim and retinal nerve fiber layer (RNFL) with associated …

High-acuity vision in primates, including humans, is mediated by a small central retinal
region called the fovea. As more accessible organisms lack a fovea, its specialized function …

Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

Age-related macular degeneration (AMD) is a leading cause of vision loss. To better
understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we …

Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the
disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is …

Importance Retinal ganglion cells endure significant metabolic stress in glaucoma but
maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Many regions in the human genome vary in length among individuals due to variable
numbers of tandem repeats (VNTRs). To assess the phenotypic impact of VNTRs genome …